News Apr 18, 2012 Read Time: Mesoblast Limited has announced that its Phase 2 clinical trial investigating the use of allogeneic, or off-the-shelf, Mesenchymal Precursor Cells (MPCs) for non-surgical restoration of degenerated intervertebral discs and treatment of low back pain has enrolled 50% of the total study patients. Spinal radiographs may reveal characteristic changes of disc disease e.g. Each disc forms a fibrocartilaginous joint (a symphysis), to allow slight movement of the vertebrae, to act as a ligament to hold the vertebrae together, and to function as a shock absorber for the spine. Wang Z, et al. Intervertebral disc repair . Supplements for Herniated Disc Repair. The intervertebral disc contributes to motion, weight bearing, and flexibility of the spine, but is susceptible to damage and morphological changes that contribute to pathology with age and injury. Intervertebral disc degeneration and repair. An intervertebral disc (or intervertebral fibrocartilage) lies between adjacent vertebrae in the vertebral column. Noriega DC, Ardura F, Hernandez-Ramajo R, Martin-Ferrero MA, Sanchez-Lite I, Toribio B, et al. Written by Martin Hughes . Intervertebral disc repair Download PDF Info Publication number US20040097927A1. Application: WO2000US24921 on 2000-09-12. Transplantation. Combined physical and medical therapies are successful in relieving pain in approximately 90% of the cases. Mochida J(1), Sakai D, Nakamura Y, Watanabe T, Yamamoto Y, Kato S. Author information: (1)Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara Kanagawa, 259-1193, Japan.jomo@is.icc.u … Several risk factors including genetic factors as well as mechanical stress, trauma and smoking, attributed to the development of intervertebral disc degeneration. Intervertebral disc degeneration is a common disease that can lead to axial skeletal pain, radiculopathy, and myelopathy. with Int.search report - World Intellectual Property Organization. 05 December, 2018 . Intervertebral disc disease (IVDD) may be strongly suspected on the basis of clinical signs especially in predisposed breeds, however, diagnostic imaging is required to confirm the diagnosis. for repair and regeneration of degenerate discs, and suggest directions for future research. 1). Intervertebral Disc Repair Phase 2 Trial Update. In response, researchers in the DISC REGENERATION project have developed a solution for those with damaged spinal discs, the predominant cause of severe and lasting back pain. The central nucleus pulposus (NP) contains large quantities of the proteoglycan aggrecan, which aggregates along chains of hyaluronan (Urban, 1996). Techniques in Regional Anesthesia and Pain Management. Intervertebral Disc Repair: Current Concepts Derek G. Ju, MD1, Linda E. Kanim, MA1, and Hyun W. Bae, MD1 Abstract Study Design: Review article. Intervertebral disc repair by allogeneic mesenchymal bone marrow cells: a randomized controlled trial. repair and make the disc particularly susceptible to injury and the aging-associated accumulation of tissue damage. (2016) 101:1945–51. Intervertebral disc (IVD) degeneration is a major cause of low back pain and represents a massive socioeconomic burden. Combined physical and medical therapies are successful in relieving pain in approximately 90% of the cases. Degenerative Disc Disease. 52. Intervertebral Disc Disease. Porcine intervertebral disc repair using allogeneic juvenile articular chondrocytes or mesenchymal stem cells. Current conservative and surgical treatments fail to restore native tissue architecture and functionality. Zhang Y(1), Chee A, Thonar EJ, An HS. Efficacy of intervertebral disc regeneration with stem cells — A systematic review and meta-analysis of animal controlled trials. Gene. Current treatments for IDD mainly depend on conservative therapies and spinal surgeries that are only able to relieve the symptoms but do not address the cause of the degeneration and even accelerate the degeneration of adjacent segments. Branko Skovrlj, Sheeraz Qureshi, Kern Singh, Mesenchymal stem cells for intervertebral disc repair and regeneration, Seminars in Spine Surgery, 10.1053/j.semss.2015.03.002, 27, 2, (76-81), (2015). doi: 10.1097/TP.0000000000001484. Structure and function of the intervertebral disc The intervertebral disc consists of multiple, structurally distinct anatomical regions (Fig. Current understanding of safety and efficacy of stem cell therapy for discogenic pain — A systematic review of human studies. INTERVERTEBRAL DISC REPAIR (PAT - WO0195818) YEUNG Jeffrey E. YEUNG, Jeffrey, E. Patent: Publ.of the Int.Appl. Developments in intervertebral disc disease research: pathophysiology, mechanobiology, and therapeutics Kathryn T. Weber & Timothy D. Jacobsen & Robert Maidhof & Justin Virojanapa & Chris Overby & Ona Bloom & Shaheda Quraishi & Mitchell Levine & Nadeen O. Chahine Published online: 19 February 2015 # Springer Science+Business Media New York 2015 Abstract Low back pain is a … L. Orozco, R. Soler, C. Morera, et al.Intervertebral disc repair by autologous mesenchymal bone marrow cells: a pilot study Transplantation, 92 (2011), pp. Crossref. Intervertebral disc repair, cell transplantation, nucleus pulposus cells, mesenchymal stromal cells, cell-to-cell contact co-culture, safety of activated nucleus pulposus cells. Neurosurg. 822-828 View Record in Scopus Google Scholar Intervertebral disc repair with activated nucleus pulposus cell transplantation: a three-year, prospective clinical study of its safety. Intervertebral disk repair by protein, gene, or cell injection: a framework for rehabilitation-focused biologics in the spine. The team used modelling to determine the complexity of the stresses placed on … * Address for correspondence: Prof. Joji Mochida Department of Orthopaedic Surgery, Surgical Science. Spinal disc herniations, notes MayoClinic.com, are particularly common in people between the ages of 35 and 45, people who are carrying excess … Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) They have developed a new surgical approach and the necessary materials that enable surgeons to repair damaged intervertebral discs. Hunt CL, et al. Cervical vertebra with intervertebral disc . Kato S. Intervertebral disc repair with activated nucleus pulposus. safety. Accessed 11/29/2020. Accessed 11/29/2020. Features of Disc Aging Intervertebral discs appear to undergo age-related degenerative changes earlier in life than other tis-sues.19,20 Based on studies of humans and different animal models (Table 1), these age-related changes Eur Cell Mater. cell transplantation: a three-year, prospective clinical study of its. La dégénérescence du disque intervertébral est une des causes principales de lombalgie, une affection douloureuse et invalidante qui représente un problème de santé publique majeur. 44. Intervertebral disc degeneration (IDD) is a common orthopedic disease associated with mechanical changes that may result in significant pain. intervertebral disc disc repair repair intervertebral Prior art date 2000-06-12 Legal status (The legal status is an assumption and is not a legal conclusion. 2015;564:1. Pathomechanism of intervertebral disc degeneration. However, the remaining 10% become chronic and generate a serious public health problem, as chronic low-back pain ruins both the life quality and the … Tissue Eng Part A. PubMed Abstract | CrossRef Full Text | Google Scholar. Tokai University School of Medicine 143 Shimokasuya. Dowdell J, Erwin M, Choma T, et al. Enhancing intervertebral disc repair and regeneration through biology: platelet-rich plasma as an alternative strategy Shan-Zheng Wang1†, Yun-Feng Rui1*†, Qi Tan2 and Chen Wang1* Abstract Intervertebral disc degeneration (IDD) is a common orthopedic disease associated with mechanical changes that may result in significant pain. One approach to such repair is to supplement the degenerate nucleus with cells that are capable of aggrecan synthesis. Doctors have found it difficult to repair herniated and degenerated discs, although they have certainly approached the problem from multiple angles of attack. Author information: (1)Departments of Physical Medicine & Rehabilitation, Orthopedic Surgery, and Biochemistry, Rush University Medical Center, Chicago, IL, USA. Biological repair of intervertebral disc degeneration should strive to restore aggrecan content to its optimal functional level. Intervertebral disc (IVD) disorders, especially degenerative disc disease, reduce the quality of life, and are short of effective therapy. 2017; 80(3 Suppl): S46–S54. National Center for Advancing Translational Sciences. Intervertebral disc repair utilizing principles of tissue Molecular Sciences Review Intervertebral Disc Nucleus Repair: Hype or Hope? Abstract. Publication: 2001-12-20. 2015;19:32. 2015;29:202-212. Yejia_zhang@rush.edu A disc herniation, defined as a rupture of the outer portion of one or more of your intervertebral discs, is a relatively common health complaint among Americans. Intervertebral disc degeneration is a very common disease that can lead to axial skeletal pain, radiculopathy, and myelopathy. Degenerative disc disease (DDD) is a medical condition in which there are anatomic changes and a loss of function of varying degrees of one or more intervertebral discs of the spine of sufficient magnitude as to cause symptoms. United States Patent Application 20040097927 . Accessed 11/29/2020. Structure. Each disk is a flat, circular capsule about an inch in diameter and one-quarter inch thick. US20040097927A1 US10/470,181 US47018103A US2004097927A1 US 20040097927 A1 US20040097927 A1 US 20040097927A1 US 47018103 A US47018103 A US 47018103A US 2004097927 A1 US2004097927 A1 US 2004097927A1 Authority US United States Prior art keywords compression disc … Objective: A review of the literature on current strategies utilized in intervertebral regeneration and repair efforts. Doctors call them intervertebral disks. Kind Code: A1 . 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